P&O Mediterranean Cruises

It is one of the world’s most popular holiday destinations, and when guests sail there with P&O Cruises, they will understand what makes the Mediterranean such an incredible cruising experience. From world-renowned cuisines to beaches that have to be seen to be believed, this destination has no shortage of ways to impress cruisers.

P&O West Mediterranean Price Drop

Why Sail with P&O Cruises to the Mediterranean?

For 180 years, P&O Cruises has promised adventure and fun and delivered on that promise time and time again. Across its exceptional fleet, the cruise line offers everything guests could need to enjoy every moment of their Mediterranean cruise, from international dining venues to kids’ clubs and fitness facilities.

As they explore the Mediterranean, P&O Cruises ensures that families and couples can make the most of every moment. Its variety of cabins and staterooms means every party can feel right at home, no matter where they are in the region, and P&O’s team of exceptional chefs can echo in-port experiences with dishes that explore the Mediterranean’s wealth of culinary flair.

What Are the Best P&O Mediterranean Cruise Destinations?

The Mediterranean is such a rich and diverse region, home to so many historic nations and culinary favourites. With a P&O itinerary, guests can experience it all, enjoying exceptional British service along the way. Here are some of the top ports that guests can discover with P&O Mediterranean cruises:

P&O cruises price drops

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Frequently Asked Questions

Guests can choose the length of the P&O Mediterranean cruise that suits them. The shortest voyages range from 6 to 9 nights, primarily sailing from Malta. For longer voyages, guests can sail around the Mediterranean for up to 24 nights (13 ports), sailing from Southampton. 

The shoulder seasons of September to November and March to May offer the best deals for sailing around the Mediterranean. These periods combine slightly cooler weather with fewer crowds.

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Enjoy Last-Minute Voyages from P&O Cruises

With 180 years of experience delivering exceptional holidays, P&O Cruises has all the facilities and expertise guests need to make their last-minute travel dreams a reality! If the urge to sail strikes, choose from a wide range of destinations and itineraries and get set for an escape that feels even better without the wait.

Last-Minute Cruises

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P&O Cruises
Mediterranean

We found

241 cruises

Arcadia, Mediterranean
1 / 27
Discount
P&O Cruises
Duration
19 nights
Date
11 Nov 2026
Ship
Arcadia
  • Departure - Southampton, Great Britain
  • 9 stops  
  • Arrival - Southampton, Great Britain
£1199
From
£1176
Price per person / inside stateroom
Aurora, Mediterranean
1 / 27
Discount
P&O Cruises
Duration
14 nights
Date
27 Nov 2026
Ship
Aurora
  • Departure - Southampton, Great Britain
  • 8 stops  
  • Arrival - Southampton, Great Britain
£999
From
£980
Price per person / inside stateroom
Arcadia, Mediterranean
1 / 27
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P&O Cruises
Duration
18 nights
Date
3 Dec 2026
Ship
Arcadia
  • Departure - Southampton, Great Britain
  • 9 stops  
  • Arrival - Southampton, Great Britain
£1699
From
£1666
Price per person / inside stateroom
Azura, Mediterranean
1 / 31
Discount
P&O Cruises
Duration
17 nights
Date
12 Dec 2026
Ship
Azura
  • Departure - Santa Cruz, Tenerife
  • 13 stops  
  • Arrival - Malaga, Spain
£999
From
£980
Price per person / inside stateroom
Azura, Mediterranean
1 / 31
Discount
P&O Cruises
Duration
17 nights
Date
12 Dec 2026
Ship
Azura
  • Departure - Santa Cruz, Tenerife
  • 13 stops  
  • Arrival - Malaga, Spain
£999
From
£980
Price per person / inside stateroom
Azura, Mediterranean
1 / 31
Discount
P&O Cruises
Duration
10 nights
Date
18 Dec 2026
Ship
Azura
  • Departure - Santa Cruz, Tenerife
  • 8 stops  
  • Arrival - Malaga, Spain
£1049
From
£1029
Price per person / inside stateroom
Azura, Mediterranean
1 / 31
Discount
P&O Cruises
Duration
10 nights
Date
18 Dec 2026
Ship
Azura
  • Departure - Santa Cruz, Tenerife
  • 8 stops  
  • Arrival - Malaga, Spain
£1049
From
£1029
Price per person / inside stateroom
Azura, Mediterranean
1 / 31
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P&O Cruises
Duration
21 nights
Date
18 Dec 2026
Ship
Azura
  • Departure - Santa Cruz, Tenerife
  • 16 stops  
  • Arrival - Santa Cruz, Tenerife
£1699
From
£1666
Price per person / oceanview stateroom
Azura, Mediterranean
1 / 31
Discount
P&O Cruises
Duration
21 nights
Date
18 Dec 2026
Ship
Azura
  • Departure - Santa Cruz, Tenerife
  • 16 stops  
  • Arrival - Santa Cruz, Tenerife
£1699
From
£1666
Price per person / oceanview stateroom
Azura, Mediterranean
1 / 31
Discount
P&O Cruises
Duration
10 nights
Date
19 Dec 2026
Ship
Azura
  • Departure - Santa Cruz, Tenerife
  • 8 stops  
  • Arrival - Malaga, Spain
£1129
From
£1107
Price per person / inside stateroom
Azura, Mediterranean
1 / 31
Discount
P&O Cruises
Duration
10 nights
Date
19 Dec 2026
Ship
Azura
  • Departure - Santa Cruz, Tenerife
  • 8 stops  
  • Arrival - Malaga, Spain
£1129
From
£1107
Price per person / inside stateroom
Azura, Mediterranean
1 / 31
Discount
P&O Cruises
Duration
21 nights
Date
19 Dec 2026
Ship
Azura
  • Departure - Santa Cruz, Tenerife
  • 16 stops  
  • Arrival - Santa Cruz, Tenerife
£1399
From
£1372
Price per person / inside stateroom
Azura, Mediterranean
1 / 31
Discount
P&O Cruises
Duration
21 nights
Date
19 Dec 2026
Ship
Azura
  • Departure - Santa Cruz, Tenerife
  • 16 stops  
  • Arrival - Santa Cruz, Tenerife
£1399
From
£1372
Price per person / inside stateroom
Azura, Mediterranean
1 / 31
Discount
P&O Cruises
Duration
11 nights
Date
28 Dec 2026
Ship
Azura
  • Departure - Malaga, Spain
  • 9 stops  
  • Arrival - Santa Cruz, Tenerife
£949
From
£931
Price per person / oceanview stateroom
Azura, Mediterranean
1 / 31
Discount
P&O Cruises
Duration
11 nights
Date
28 Dec 2026
Ship
Azura
  • Departure - Malaga, Spain
  • 9 stops  
  • Arrival - Santa Cruz, Tenerife
£949
From
£931
Price per person / oceanview stateroom
Ventura, Mediterranean
1 / 25
Discount
P&O Cruises
Duration
14 nights
Date
12 Feb 2027
Ship
Ventura
  • Departure - Southampton, Great Britain
  • 9 stops  
  • Arrival - Southampton, Great Britain
£1049
From
£1029
Price per person / inside stateroom
Ventura, Mediterranean
1 / 25
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P&O Cruises
Duration
21 nights
Date
26 Feb 2027
Ship
Ventura
  • Departure - Southampton, Great Britain
  • 12 stops  
  • Arrival - Southampton, Great Britain
£1499
From
£1470
Price per person / inside stateroom
Show all departures (2)
Azura, Mediterranean
1 / 31
Discount
P&O Cruises
Duration
20 nights
Date
12 Mar 2027
Ship
Azura
  • Departure - Santa Cruz, Tenerife
  • 14 stops  
  • Arrival - Valletta, Malta
£1389
From
£1362
Price per person / inside stateroom
Azura, Mediterranean
1 / 31
Discount
P&O Cruises
Duration
20 nights
Date
12 Mar 2027
Ship
Azura
  • Departure - Santa Cruz, Tenerife
  • 14 stops  
  • Arrival - Valletta, Malta
£1389
From
£1362
Price per person / inside stateroom
Azura, Mediterranean
1 / 31
Discount
P&O Cruises
Duration
19 nights
Date
13 Mar 2027
Ship
Azura
  • Departure - Santa Cruz, Tenerife
  • 13 stops  
  • Arrival - Valletta, Malta
£1299
From
£1274
Price per person / inside stateroom
20 of 241 pcs