South America Cruises

South America is a vast continent that offers a unique and exciting experience when cruising. From the rugged mountains of the Andes to the lush Amazon rainforest and vibrant coastal cities, South America has something for everyone. If you are looking for cruises to South America we can help you find what you are looking for, just call our friendly Cruise Expert on 01246 819 819 for advice.

Explore South America

Diverse landscapes, culture, and adventure opportunities; South America is an exciting destination with a lust for life that few others can compete with. You can explore ancient ruins, encounter exotic wildlife, indulge in delicious cuisine, and experience vibrant cities. The music is loud, the food is good, and the dancing doesn’t stop until the early hours. It’s a once-in-a-lifetime experience.

Popular cruise lines for South America cruises

Looking to sail to South America? These cruise lines specialise in holidays that will give you the ultimate experience!

Destinations

South America

We found

3 cruise packages and 268 cruises

AmaMelodia, Magdalena River
1 / 4
5 % off
AmaWaterways
Duration
7 nights
Date
11 Nov 2026
Ship
AmaMelodia
  • Departure - Barranquilla, Colombia
  • 8 stops  
  • Arrival - Cartagena, Colombia
£5084
From
£4830
Price per person / balcony stateroom
Show all departures (39)
Available promotion:
Return UK flights from London or Manchester and overseas transfers included^
MSC Divina, South America
1 / 27
Discount
MSC Cruises
Duration
4 nights
Date
12 Nov 2026
Ship
MSC Divina
  • Departure - Salvador de Bahia, Brazil
  • 3 stops  
  • Arrival - Santos (São Paulo), Brazil
£369
From
£360
Price per person / oceanview stateroom
Available promotion:
MSC CRUISES BLACK FRIDAY PREVIEW SALE - SAVE UP TO 30%
AmaMagdalena, Magdalena River
1 / 4
5 % off
AmaWaterways
Duration
7 nights
Date
14 Nov 2026
Ship
AmaMagdalena
  • Departure - Barranquilla, Colombia
  • 8 stops  
  • Arrival - Cartagena, Colombia
£5084
From
£4830
Price per person / balcony stateroom
Show all departures (34)
Available promotion:
Return UK flights from London or Manchester and overseas transfers included^
AmaMelodia, Magdalena River
1 / 4
5 % off
AmaWaterways
Duration
7 nights
Date
18 Nov 2026
Ship
AmaMelodia
  • Departure - Cartagena, Colombia
  • 8 stops  
  • Arrival - Barranquilla, Colombia
£5084
From
£4830
Price per person / balcony stateroom
Show all departures (33)
Available promotion:
Return UK flights from London or Manchester and overseas transfers included^
MSC Musica, South America
1 / 19
Discount
MSC Cruises
Duration
3 nights
Date
23 Nov 2026
Ship
MSC Musica
  • Departure - Santos (São Paulo), Brazil
  • 3 stops  
  • Arrival - Santos (São Paulo), Brazil
£269
From
£263
Price per person / inside stateroom
Show all departures (3)
Available promotion:
MSC CRUISES BLACK FRIDAY PREVIEW SALE - SAVE UP TO 30%
Viking Octantis, South America
1 / 14
Discount
Viking Cruises
Duration
12 nights
Date
23 Nov 2026
Ship
Viking Octantis
  • Departure - Valparaiso, Chile
  • 8 stops  
  • Arrival - Ushuaia, Argentina
£9990
From
£9591
Price per person / suite
Available promotion:
Return UK flights from London or Manchester and overseas transfers included^
MSC Musica, South America
1 / 19
Discount
MSC Cruises
Duration
4 nights
Date
26 Nov 2026
Ship
MSC Musica
  • Departure - Santos (São Paulo), Brazil
  • 4 stops  
  • Arrival - Santos (São Paulo), Brazil
£319
From
£312
Price per person / inside stateroom
Show all departures (2)
Available promotion:
MSC CRUISES BLACK FRIDAY PREVIEW SALE - SAVE UP TO 30%
MSC Virtuosa, South America
1 / 39
Discount
MSC Cruises
Duration
4 nights
Date
28 Nov 2026
Ship
MSC Virtuosa
  • Departure - Salvador de Bahia, Brazil
  • 3 stops  
  • Arrival - Santos (São Paulo), Brazil
£1439
From
£1404
Price per person / suite
Available promotion:
MSC CRUISES BLACK FRIDAY PREVIEW SALE - SAVE UP TO 30%
MSC Seaview, South America
1 / 33
Discount
MSC Cruises
Duration
3 nights
Date
29 Nov 2026
Ship
MSC Seaview
  • Departure - Santos (São Paulo), Brazil
  • 3 stops  
  • Arrival - Santos (São Paulo), Brazil
£399
From
£390
Price per person / inside stateroom
Available promotion:
MSC CRUISES BLACK FRIDAY PREVIEW SALE - SAVE UP TO 30%
MSC Divina, South America
1 / 27
Discount
MSC Cruises
Duration
4 nights
Date
29 Nov 2026
Ship
MSC Divina
  • Departure - Santos (São Paulo), Brazil
  • 4 stops  
  • Arrival - Santos (São Paulo), Brazil
£439
From
£429
Price per person / inside stateroom
Available promotion:
MSC CRUISES BLACK FRIDAY PREVIEW SALE - SAVE UP TO 30%
MSC Splendida, South America
1 / 29
Discount
MSC Cruises
Duration
7 nights
Date
29 Nov 2026
Ship
MSC Splendida
  • Departure - Rio de Janeiro, Brazil
  • 4 stops  
  • Arrival - Rio de Janeiro, Brazil
£1019
From
£971
Price per person / balcony stateroom
Available promotion:
MSC CRUISES BLACK FRIDAY PREVIEW SALE - SAVE UP TO 30%
MSC Musica, South America
1 / 19
Discount
MSC Cruises
Duration
3 nights
Date
30 Nov 2026
Ship
MSC Musica
  • Departure - Santos (São Paulo), Brazil
  • 3 stops  
  • Arrival - Santos (São Paulo), Brazil
£239
From
£234
Price per person / inside stateroom
Available promotion:
MSC CRUISES BLACK FRIDAY PREVIEW SALE - SAVE UP TO 30%
MSC Virtuosa, South America
1 / 39
Discount
MSC Cruises
Duration
3 nights
Date
2 Dec 2026
Ship
MSC Virtuosa
  • Departure - Santos (São Paulo), Brazil
  • 3 stops  
  • Arrival - Santos (São Paulo), Brazil
£309
From
£302
Price per person / oceanview stateroom
Available promotion:
MSC CRUISES BLACK FRIDAY PREVIEW SALE - SAVE UP TO 30%
MSC Seaview, South America
1 / 33
Discount
MSC Cruises
Duration
3 nights
Date
2 Dec 2026
Ship
MSC Seaview
  • Departure - Santos (São Paulo), Brazil
  • 3 stops  
  • Arrival - Santos (São Paulo), Brazil
£359
From
£351
Price per person / oceanview stateroom
Available promotion:
MSC CRUISES BLACK FRIDAY PREVIEW SALE - SAVE UP TO 30%
MSC Musica, South America
1 / 19
Discount
MSC Cruises
Duration
3 nights
Date
3 Dec 2026
Ship
MSC Musica
  • Departure - Santos (São Paulo), Brazil
  • 3 stops  
  • Arrival - Santos (São Paulo), Brazil
£239
From
£234
Price per person / inside stateroom
Show all departures (3)
Available promotion:
MSC CRUISES BLACK FRIDAY PREVIEW SALE - SAVE UP TO 30%
MSC Splendida, South America
1 / 29
Discount
MSC Cruises
Duration
3 nights
Date
3 Dec 2026
Ship
MSC Splendida
  • Departure - Buenos Aires, Argentina
  • 2 stops  
  • Arrival - Rio de Janeiro, Brazil
£619
From
£604
Price per person / balcony stateroom
Available promotion:
MSC CRUISES BLACK FRIDAY PREVIEW SALE - SAVE UP TO 30%
MSC Splendida, South America
1 / 29
Discount
MSC Cruises
Duration
8 nights
Date
3 Dec 2026
Ship
MSC Splendida
  • Departure - Buenos Aires, Argentina
  • 6 stops  
  • Arrival - Buenos Aires, Argentina
£699
From
£666
Price per person / inside stateroom
Show all departures (8)
Available promotion:
MSC CRUISES BLACK FRIDAY PREVIEW SALE - SAVE UP TO 30%
MSC Virtuosa, South America
1 / 39
Discount
MSC Cruises
Duration
3 nights
Date
5 Dec 2026
Ship
MSC Virtuosa
  • Departure - Santos (São Paulo), Brazil
  • 3 stops  
  • Arrival - Salvador de Bahia, Brazil
£339
From
£331
Price per person / inside stateroom
Available promotion:
MSC CRUISES BLACK FRIDAY PREVIEW SALE - SAVE UP TO 30%
MSC Virtuosa, South America
1 / 39
Discount
MSC Cruises
Duration
4 nights
Date
5 Dec 2026
Ship
MSC Virtuosa
  • Departure - Santos (São Paulo), Brazil
  • 4 stops  
  • Arrival - Maceió, Brazil
£471
From
£460
Price per person / inside stateroom
Show all departures (2)
Available promotion:
MSC CRUISES BLACK FRIDAY PREVIEW SALE - SAVE UP TO 30%
MSC Virtuosa, South America
1 / 39
Discount
MSC Cruises
Duration
7 nights
Date
5 Dec 2026
Ship
MSC Virtuosa
  • Departure - Santos (São Paulo), Brazil
  • 5 stops  
  • Arrival - Santos (São Paulo), Brazil
£664
From
£633
Price per person / inside stateroom
Show all departures (11)
Available promotion:
MSC CRUISES BLACK FRIDAY PREVIEW SALE - SAVE UP TO 30%
20 of 268 pcs