MSC Mediterranean Cruises

Summer escapes across the Mediterranean get even better when paired with the exceptional facilities and itineraries offered by MSC Cruises. As guests look ahead to exciting city tours, exquisitely prepared meals and locally sourced wine tastings, MSC makes every moment special with onboard entertainment, dining and wellness facilities to remember.

Why Sail with MSC Cruises to the Mediterranean?

There’s a reason why the Mediterranean is one of the ultimate summer destinations for holidaymakers across the world, but with MSC Cruises, this region gets even better. From the thrills of an onboard 4D cinema and West End-style theatre to the perks of satellite Wi-Fi, this cruise line makes sailing feel seamless and luxurious.

Whether it’s a family holiday to be cherished or a romantic couples retreat, MSC makes exploring the Mediterranean an adventure in more ways than one. With its convenient buffet-style dining options and speciality venues like Le Grill and Paxos, MSC allows guests to discover new flavours from the region or delve into their favourites from across the globe.

What Are the Best MSC Mediterranean Cruise Destinations?

When it comes to historic significance and culinary excellence, the Mediterranean makes for a leading cruise destination that certainly won’t disappoint. Here are some of the top ports that guests can discover with MSC Mediterranean cruises:

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Frequently Asked Questions

Yes, MSC offers Mediterranean itineraries departing from Southampton. 

Yes! MSC offers fly cruises that set sail around the Mediterranean, departing from ports such as Barcelona, Venice and Rome.

These itineraries can range in duration, from mini cruises of just 1 or 2 nights to those lasting more than 20 nights.

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Keep up to date with the latest cruise news and our cruise guides, as well as exciting ship spotlights shedding light on your favourite ships and helping you find new favourites to explore.

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Explore Winter Sun Holidays from MSC Cruises

MSC Cruises lets you see the world like never before, but why wait until the busy summer months to enjoy the voyage of a lifetime? Make next winter one to remember with a cruise to some of the sunniest ports and beaches across Europe, the Caribbean, and more. Escape the cold weather and look forward to the ultimate getaway with MSC!

Winter Sun Holidays

Book an MSC Mediterranean Cruise Today

MSC Cruises
Mediterranean

We found

1 cruise package and 491 cruises

Rome, Rugby & the Mediterranean with MSC Cruises
10
nights
Departure12 Feb 2027
Fr. £2100
MSC Splendida, Mediterranean
1 / 29
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MSC Cruises
Duration
4 nights
Date
11 Nov 2026
Ship
MSC Splendida
  • Departure - Cagliari (Sardinia), Italy
  • 4 stops  
  • Arrival - Barcelona, Spain
£371
From
£362
Price per person / balcony stateroom
Available promotion:
MSC CRUISES BLACK FRIDAY PREVIEW SALE - SAVE UP TO 30%
MSC Orchestra, Mediterranean
1 / 21
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MSC Cruises
Duration
7 nights
Date
11 Nov 2026
Ship
MSC Orchestra
  • Departure - Istanbul, Turkey
  • 6 stops  
  • Arrival - Istanbul, Turkey
£609
From
£581
Price per person / inside stateroom
Show all departures (6)
Available promotion:
MSC CRUISES BLACK FRIDAY PREVIEW SALE - SAVE UP TO 30%
MSC Euribia, Mediterranean
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MSC Cruises
Duration
7 nights
Date
11 Nov 2026
Ship
MSC Euribia
  • Departure - Palermo, Sicily
  • 7 stops  
  • Arrival - Palermo, Sicily
£629
From
£600
Price per person / inside stateroom
Show all departures (21)
Available promotion:
MSC CRUISES BLACK FRIDAY PREVIEW SALE - SAVE UP TO 30%
MSC Seaview, Mediterranean
1 / 33
MSC Cruises
Duration
2 nights
Date
12 Nov 2026
Ship
MSC Seaview
  • Departure - Tarragona, Spain
  • 3 stops  
  • Arrival - Genoa, Italy
From
£109
Price per person / inside stateroom
Available promotion:
MSC CRUISES BLACK FRIDAY PREVIEW SALE - SAVE UP TO 30%
MSC World Europa, Mediterranean
1 / 25
MSC Cruises
Duration
2 nights
Date
12 Nov 2026
Ship
MSC World Europa
  • Departure - Barcelona, Spain
  • 3 stops  
  • Arrival - Genoa, Italy
From
£285
Price per person / balcony stateroom
Available promotion:
MSC CRUISES BLACK FRIDAY PREVIEW SALE - SAVE UP TO 30%
MSC World Europa, Mediterranean
1 / 25
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MSC Cruises
Duration
5 nights
Date
12 Nov 2026
Ship
MSC World Europa
  • Departure - Barcelona, Spain
  • 6 stops  
  • Arrival - Marseille, France
£547
From
£534
Price per person / balcony stateroom
Available promotion:
MSC CRUISES BLACK FRIDAY PREVIEW SALE - SAVE UP TO 30%
MSC Seaview, Mediterranean
1 / 33
MSC Cruises
Duration
1 night
Date
13 Nov 2026
Ship
MSC Seaview
  • Departure - Marseille, France
  • 2 stops  
  • Arrival - Genoa, Italy
From
£59
Price per person / inside stateroom
Available promotion:
MSC CRUISES BLACK FRIDAY PREVIEW SALE - SAVE UP TO 30%
MSC World Europa, Mediterranean
1 / 25
MSC Cruises
Duration
1 night
Date
13 Nov 2026
Ship
MSC World Europa
  • Departure - Marseille, France
  • 2 stops  
  • Arrival - Genoa, Italy
From
£59
Price per person / inside stateroom
Available promotion:
MSC CRUISES BLACK FRIDAY PREVIEW SALE - SAVE UP TO 30%
MSC Magnifica, Mediterranean
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MSC Cruises
Duration
7 nights
Date
13 Nov 2026
Ship
MSC Magnifica
  • Departure - Barcelona, Spain
  • 7 stops  
  • Arrival - Barcelona, Spain
£359
From
£342
Price per person / inside stateroom
Show all departures (3)
Available promotion:
MSC CRUISES BLACK FRIDAY PREVIEW SALE - SAVE UP TO 30%
MSC World Europa, Mediterranean
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MSC Cruises
Duration
4 nights
Date
14 Nov 2026
Ship
MSC World Europa
  • Departure - Genoa, Italy
  • 5 stops  
  • Arrival - Barcelona, Spain
£319
From
£312
Price per person / inside stateroom
Available promotion:
MSC CRUISES BLACK FRIDAY PREVIEW SALE - SAVE UP TO 30%
MSC Magnifica, Mediterranean
1 / 24
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MSC Cruises
Duration
7 nights
Date
14 Nov 2026
Ship
MSC Magnifica
  • Departure - Marseille, France
  • 7 stops  
  • Arrival - Marseille, France
£419
From
£400
Price per person / inside stateroom
Show all departures (3)
Available promotion:
MSC CRUISES BLACK FRIDAY PREVIEW SALE - SAVE UP TO 30%
MSC World Europa, Mediterranean
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MSC Cruises
Duration
3 nights
Date
14 Nov 2026
Ship
MSC World Europa
  • Departure - Genoa, Italy
  • 4 stops  
  • Arrival - Marseille, France
£429
From
£419
Price per person / suite
Available promotion:
MSC CRUISES BLACK FRIDAY PREVIEW SALE - SAVE UP TO 30%
MSC Euribia, Mediterranean
1 / 32
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MSC Cruises
Duration
7 nights
Date
14 Nov 2026
Ship
MSC Euribia
  • Departure - Barcelona, Spain
  • 7 stops  
  • Arrival - Barcelona, Spain
£429
From
£409
Price per person / inside stateroom
Show all departures (22)
Available promotion:
MSC CRUISES BLACK FRIDAY PREVIEW SALE - SAVE UP TO 30%
MSC Orchestra, Mediterranean
1 / 21
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MSC Cruises
Duration
7 nights
Date
14 Nov 2026
Ship
MSC Orchestra
  • Departure - Bari, Italy
  • 6 stops  
  • Arrival - Bari, Italy
£669
From
£638
Price per person / balcony stateroom
Show all departures (8)
Available promotion:
MSC CRUISES BLACK FRIDAY PREVIEW SALE - SAVE UP TO 30%
MSC Sinfonia, Mediterranean
1 / 30
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MSC Cruises
Duration
6 nights
Date
14 Nov 2026
Ship
MSC Sinfonia
  • Departure - Valencia, Spain
  • 6 stops  
  • Arrival - Valencia, Spain
£779
From
£742
Price per person / suite
Available promotion:
MSC CRUISES BLACK FRIDAY PREVIEW SALE - SAVE UP TO 30%
MSC Lirica, Mediterranean
1 / 15
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MSC Cruises
Duration
11 nights
Date
14 Nov 2026
Ship
MSC Lirica
  • Departure - Split, Croatia
  • 9 stops  
  • Arrival - Split, Croatia
£876
From
£835
Price per person / inside stateroom
Show all departures (4)
Available promotion:
MSC CRUISES BLACK FRIDAY PREVIEW SALE - SAVE UP TO 30%
MSC Sinfonia, Mediterranean
1 / 30
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MSC Cruises
Duration
7 nights
Date
15 Nov 2026
Ship
MSC Sinfonia
  • Departure - Barcelona, Spain
  • 7 stops  
  • Arrival - Barcelona, Spain
£369
From
£352
Price per person / inside stateroom
Available promotion:
MSC CRUISES BLACK FRIDAY PREVIEW SALE - SAVE UP TO 30%
MSC Euribia, Mediterranean
1 / 32
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MSC Cruises
Duration
7 nights
Date
15 Nov 2026
Ship
MSC Euribia
  • Departure - Marseille, France
  • 7 stops  
  • Arrival - Marseille, France
£439
From
£419
Price per person / oceanview stateroom
Show all departures (21)
Available promotion:
MSC CRUISES BLACK FRIDAY PREVIEW SALE - SAVE UP TO 30%
MSC Lirica, Mediterranean
1 / 15
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MSC Cruises
Duration
11 nights
Date
15 Nov 2026
Ship
MSC Lirica
  • Departure - Venice, Italy
  • 9 stops  
  • Arrival - Venice, Italy
£837
From
£798
Price per person / oceanview stateroom
Show all departures (6)
Available promotion:
MSC CRUISES BLACK FRIDAY PREVIEW SALE - SAVE UP TO 30%
MSC Sinfonia, Mediterranean
1 / 30
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MSC Cruises
Duration
7 nights
Date
16 Nov 2026
Ship
MSC Sinfonia
  • Departure - Marseille, France
  • 7 stops  
  • Arrival - Marseille, France
£419
From
£400
Price per person / inside stateroom
Available promotion:
MSC CRUISES BLACK FRIDAY PREVIEW SALE - SAVE UP TO 30%
MSC Orchestra, Mediterranean
1 / 21
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MSC Cruises
Duration
7 nights
Date
16 Nov 2026
Ship
MSC Orchestra
  • Departure - Athens (Piraeus), Greece
  • 6 stops  
  • Arrival - Athens (Piraeus), Greece
£439
From
£419
Price per person / inside stateroom
Show all departures (8)
Available promotion:
MSC CRUISES BLACK FRIDAY PREVIEW SALE - SAVE UP TO 30%
MSC Euribia, Mediterranean
1 / 32
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MSC Cruises
Duration
7 nights
Date
16 Nov 2026
Ship
MSC Euribia
  • Departure - Genoa, Italy
  • 7 stops  
  • Arrival - Genoa, Italy
£481
From
£459
Price per person / inside stateroom
Show all departures (21)
Available promotion:
MSC CRUISES BLACK FRIDAY PREVIEW SALE - SAVE UP TO 30%
MSC Sinfonia, Mediterranean
1 / 30
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MSC Cruises
Duration
7 nights
Date
17 Nov 2026
Ship
MSC Sinfonia
  • Departure - Genoa, Italy
  • 7 stops  
  • Arrival - Genoa, Italy
£359
From
£342
Price per person / inside stateroom
Available promotion:
MSC CRUISES BLACK FRIDAY PREVIEW SALE - SAVE UP TO 30%
MSC Euribia, Mediterranean
1 / 32
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MSC Cruises
Duration
7 nights
Date
17 Nov 2026
Ship
MSC Euribia
  • Departure - Naples, Italy
  • 7 stops  
  • Arrival - Naples, Italy
£509
From
£485
Price per person / balcony stateroom
Show all departures (20)
Available promotion:
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MSC Sinfonia, Mediterranean
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MSC Cruises
Duration
8 nights
Date
20 Nov 2026
Ship
MSC Sinfonia
  • Departure - Valencia, Spain
  • 8 stops  
  • Arrival - Valencia, Spain
£369
From
£352
Price per person / inside stateroom
Show all departures (2)
Available promotion:
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MSC Sinfonia, Mediterranean
1 / 30
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MSC Cruises
Duration
6 nights
Date
20 Nov 2026
Ship
MSC Sinfonia
  • Departure - Valencia, Spain
  • 7 stops  
  • Arrival - Civitavecchia (Rome), Italy
£409
From
£390
Price per person / oceanview stateroom
Available promotion:
MSC CRUISES BLACK FRIDAY PREVIEW SALE - SAVE UP TO 30%
MSC Sinfonia, Mediterranean
1 / 30
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MSC Cruises
Duration
7 nights
Date
22 Nov 2026
Ship
MSC Sinfonia
  • Departure - Barcelona, Spain
  • 7 stops  
  • Arrival - Barcelona, Spain
£379
From
£361
Price per person / inside stateroom
Show all departures (2)
Available promotion:
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MSC Sinfonia, Mediterranean
1 / 30
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MSC Cruises
Duration
7 nights
Date
23 Nov 2026
Ship
MSC Sinfonia
  • Departure - Marseille, France
  • 7 stops  
  • Arrival - Marseille, France
£869
From
£828
Price per person / suite
Show all departures (12)
Available promotion:
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MSC Sinfonia, Mediterranean
1 / 30
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MSC Cruises
Duration
7 nights
Date
24 Nov 2026
Ship
MSC Sinfonia
  • Departure - Genoa, Italy
  • 7 stops  
  • Arrival - Genoa, Italy
£339
From
£323
Price per person / oceanview stateroom
Show all departures (14)
Available promotion:
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MSC Sinfonia, Mediterranean
1 / 30
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MSC Cruises
Duration
7 nights
Date
26 Nov 2026
Ship
MSC Sinfonia
  • Departure - Civitavecchia (Rome), Italy
  • 7 stops  
  • Arrival - Civitavecchia (Rome), Italy
£469
From
£447
Price per person / oceanview stateroom
Show all departures (14)
Available promotion:
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MSC Sinfonia, Mediterranean
1 / 30
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MSC Cruises
Duration
7 nights
Date
28 Nov 2026
Ship
MSC Sinfonia
  • Departure - Valencia, Spain
  • 7 stops  
  • Arrival - Valencia, Spain
£359
From
£342
Price per person / inside stateroom
Show all departures (14)
Available promotion:
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MSC Magnifica, Mediterranean
1 / 24
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MSC Cruises
Duration
7 nights
Date
29 Nov 2026
Ship
MSC Magnifica
  • Departure - Genoa, Italy
  • 7 stops  
  • Arrival - Genoa, Italy
£349
From
£333
Price per person / inside stateroom
Available promotion:
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MSC Sinfonia, Mediterranean
1 / 30
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MSC Cruises
Duration
7 nights
Date
29 Nov 2026
Ship
MSC Sinfonia
  • Departure - Barcelona, Spain
  • 7 stops  
  • Arrival - Barcelona, Spain
£379
From
£361
Price per person / inside stateroom
Show all departures (13)
Available promotion:
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MSC Magnifica, Mediterranean
1 / 24
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MSC Cruises
Duration
4 nights
Date
30 Nov 2026
Ship
MSC Magnifica
  • Departure - Naples, Italy
  • 4 stops  
  • Arrival - Barcelona, Spain
£241
From
£235
Price per person / inside stateroom
Available promotion:
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MSC Magnifica, Mediterranean
1 / 24
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MSC Cruises
Duration
6 nights
Date
30 Nov 2026
Ship
MSC Magnifica
  • Departure - Naples, Italy
  • 6 stops  
  • Arrival - Genoa, Italy
£339
From
£323
Price per person / inside stateroom
Available promotion:
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MSC World Asia, Mediterranean
1 / 20
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MSC Cruises
Duration
7 nights
Date
5 Dec 2026
Ship
MSC World Asia
  • Departure - Marseille, France
  • 7 stops  
  • Arrival - Marseille, France
£554
From
£528
Price per person / inside stateroom
Show all departures (18)
Available promotion:
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MSC World Asia, Mediterranean
1 / 20
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MSC Cruises
Duration
7 nights
Date
6 Dec 2026
Ship
MSC World Asia
  • Departure - Genoa, Italy
  • 7 stops  
  • Arrival - Genoa, Italy
£559
From
£533
Price per person / inside stateroom
Show all departures (18)
Available promotion:
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MSC Lirica, Mediterranean
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MSC Cruises
Duration
10 nights
Date
6 Dec 2026
Ship
MSC Lirica
  • Departure - Split, Croatia
  • 7 stops  
  • Arrival - Split, Croatia
£617
From
£588
Price per person / oceanview stateroom
Available promotion:
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MSC Magnifica, Mediterranean
1 / 24
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MSC Cruises
Duration
10 nights
Date
6 Dec 2026
Ship
MSC Magnifica
  • Departure - Genoa, Italy
  • 9 stops  
  • Arrival - Genoa, Italy
£619
From
£590
Price per person / inside stateroom
Show all departures (2)
Available promotion:
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MSC World Asia, Mediterranean
1 / 20
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MSC Cruises
Duration
7 nights
Date
7 Dec 2026
Ship
MSC World Asia
  • Departure - Civitavecchia (Rome), Italy
  • 7 stops  
  • Arrival - Civitavecchia (Rome), Italy
£449
From
£428
Price per person / inside stateroom
Show all departures (18)
Available promotion:
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MSC Magnifica, Mediterranean
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MSC Cruises
Duration
10 nights
Date
7 Dec 2026
Ship
MSC Magnifica
  • Departure - Marseille, France
  • 9 stops  
  • Arrival - Marseille, France
£639
From
£609
Price per person / inside stateroom
Show all departures (2)
Available promotion:
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MSC Lirica, Mediterranean
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MSC Cruises
Duration
10 nights
Date
7 Dec 2026
Ship
MSC Lirica
  • Departure - Venice, Italy
  • 7 stops  
  • Arrival - Venice, Italy
£778
From
£742
Price per person / oceanview stateroom
Available promotion:
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MSC Lirica, Mediterranean
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MSC Cruises
Duration
10 nights
Date
7 Dec 2026
Ship
MSC Lirica
  • Departure - Venice, Italy
  • 7 stops  
  • Arrival - Venice, Italy
£878
From
£837
Price per person / oceanview stateroom
Available promotion:
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MSC Magnifica, Mediterranean
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MSC Cruises
Duration
7 nights
Date
8 Dec 2026
Ship
MSC Magnifica
  • Departure - Barcelona, Spain
  • 6 stops  
  • Arrival - Civitavecchia (Rome), Italy
£399
From
£381
Price per person / inside stateroom
Available promotion:
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MSC Magnifica, Mediterranean
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MSC Cruises
Duration
10 nights
Date
8 Dec 2026
Ship
MSC Magnifica
  • Departure - Barcelona, Spain
  • 9 stops  
  • Arrival - Barcelona, Spain
£536
From
£511
Price per person / inside stateroom
Show all departures (2)
Available promotion:
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MSC World Asia, Mediterranean
1 / 20
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MSC Cruises
Duration
7 nights
Date
8 Dec 2026
Ship
MSC World Asia
  • Departure - Messina, Sicily
  • 7 stops  
  • Arrival - Messina, Sicily
£622
From
£593
Price per person / inside stateroom
Show all departures (17)
Available promotion:
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MSC World Asia, Mediterranean
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MSC Cruises
Duration
7 nights
Date
11 Dec 2026
Ship
MSC World Asia
  • Departure - Barcelona, Spain
  • 7 stops  
  • Arrival - Barcelona, Spain
£499
From
£476
Price per person / inside stateroom
Show all departures (18)
Available promotion:
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MSC Magnifica, Mediterranean
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MSC Cruises
Duration
10 nights
Date
15 Dec 2026
Ship
MSC Magnifica
  • Departure - Civitavecchia (Rome), Italy
  • 9 stops  
  • Arrival - Civitavecchia (Rome), Italy
£639
From
£609
Price per person / inside stateroom
Available promotion:
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MSC Lirica, Mediterranean
1 / 15
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MSC Cruises
Duration
11 nights
Date
17 Dec 2026
Ship
MSC Lirica
  • Departure - Venice, Italy
  • 9 stops  
  • Arrival - Venice, Italy
£998
From
£951
Price per person / inside stateroom
Show all departures (2)
Available promotion:
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MSC Magnifica, Mediterranean
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MSC Cruises
Duration
10 nights
Date
25 Dec 2026
Ship
MSC Magnifica
  • Departure - Civitavecchia (Rome), Italy
  • 9 stops  
  • Arrival - Civitavecchia (Rome), Italy
£1279
From
£1219
Price per person / inside stateroom
Available promotion:
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MSC Magnifica, Mediterranean
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MSC Cruises
Duration
10 nights
Date
26 Dec 2026
Ship
MSC Magnifica
  • Departure - Genoa, Italy
  • 9 stops  
  • Arrival - Genoa, Italy
£1316
From
£1254
Price per person / inside stateroom
Available promotion:
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MSC Magnifica, Mediterranean
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MSC Cruises
Duration
10 nights
Date
27 Dec 2026
Ship
MSC Magnifica
  • Departure - Marseille, France
  • 9 stops  
  • Arrival - Marseille, France
£909
From
£866
Price per person / inside stateroom
Available promotion:
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MSC Sinfonia, Mediterranean
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MSC Cruises
Duration
7 nights
Date
28 Dec 2026
Ship
MSC Sinfonia
  • Departure - Marseille, France
  • 7 stops  
  • Arrival - Marseille, France
£814
From
£776
Price per person / inside stateroom
Available promotion:
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MSC Lirica, Mediterranean
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MSC Cruises
Duration
12 nights
Date
28 Dec 2026
Ship
MSC Lirica
  • Departure - Venice, Italy
  • 10 stops  
  • Arrival - Bari, Italy
£1019
From
£971
Price per person / oceanview stateroom
Available promotion:
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MSC Magnifica, Mediterranean
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MSC Cruises
Duration
10 nights
Date
28 Dec 2026
Ship
MSC Magnifica
  • Departure - Barcelona, Spain
  • 9 stops  
  • Arrival - Barcelona, Spain
£1163
From
£1108
Price per person / inside stateroom
Available promotion:
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MSC Orchestra, Mediterranean
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MSC Cruises
Duration
7 nights
Date
30 Dec 2026
Ship
MSC Orchestra
  • Departure - Istanbul, Turkey
  • 6 stops  
  • Arrival - Istanbul, Turkey
£859
From
£819
Price per person / inside stateroom
Show all departures (6)
Available promotion:
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MSC Orchestra, Mediterranean
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MSC Cruises
Duration
7 nights
Date
2 Jan 2027
Ship
MSC Orchestra
  • Departure - Bari, Italy
  • 6 stops  
  • Arrival - Bari, Italy
£631
From
£602
Price per person / oceanview stateroom
Show all departures (7)
Available promotion:
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MSC Orchestra, Mediterranean
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MSC Cruises
Duration
3 nights
Date
6 Jan 2027
Ship
MSC Orchestra
  • Departure - Istanbul, Turkey
  • 3 stops  
  • Arrival - Bari, Italy
£202
From
£197
Price per person / inside stateroom
Show all departures (2)
Available promotion:
MSC CRUISES BLACK FRIDAY PREVIEW SALE - SAVE UP TO 30%
MSC Lirica, Mediterranean
1 / 15
MSC Cruises
Duration
2 nights
Date
7 Jan 2027
Ship
MSC Lirica
  • Departure - Split, Croatia
  • 3 stops  
  • Arrival - Bari, Italy
From
£119
Price per person / oceanview stateroom
Available promotion:
MSC CRUISES BLACK FRIDAY PREVIEW SALE - SAVE UP TO 30%
MSC Lirica, Mediterranean
1 / 15
MSC Cruises
Duration
2 nights
Date
9 Jan 2027
Ship
MSC Lirica
  • Departure - Bari, Italy
  • 2 stops  
  • Arrival - Athens (Piraeus), Greece
From
£109
Price per person / oceanview stateroom
Available promotion:
MSC CRUISES BLACK FRIDAY PREVIEW SALE - SAVE UP TO 30%
60 of 491 pcs